Statistical Genetics and Population Genetics

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Peer-reviewed journal publications

* indicates co-first authors; # indicates corresponding authors; lab members are highlighted in bold.

In press

X Wang, Z Zhang, N Morris, T Cai, S Lee, C Wang, TW Yu, CA Walsh, X Lin. Rare variant association test in family based sequencing studies. Briefings in Bioinformatics, in press. [link] [pdf]

H Liu, Z Wang, Y Li, G Yu, X Fu, ..., C Wang, ..., S Chen, J Liu, F Zhang. Genome-wide analysis of protein-coding variants in leprosy. Journal of Investigative Dermatology, in press. [link]

J Liu, X Wan, C Wang, Ch Yang, X Zhou, C Yang. LLR: A latent low-rank approach to colocalizing genetic risk variants in multiple GWAS. Bioinformatics, in press. [link]


J Dou*, B Sun*, X Sim, JD Hughes, DF Reilly, ES Tai, J Liu, C Wang# (2017). Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data. PLOS Genetics, 13: e1007021. [link] [pdf] [supplement] [software]

W Dai, M Yang, C Wang, T Cai (2017). Sequence robust association test (SRAT) for familial data. Biometrics, 73: 876-884. [link] [pdf] [supplement]

Z Wang, BC Henn, C Wang, Y Wei, L Su, R Sun, H Chen, PJ Wagner, Q Lu, X Lin, R Wright, D Bellinger, M Kile, M Mazumdar, MM Tellez-Rojo, L Schnaas, DC Christiani (2017). Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environmental Health, 16: 81. [link] [pdf]

D Taliun#, S Chothani, S Schonherr, L Forer, M Boehnke, GR Abecasis, C Wang# (2017). LASER server: ancestry tracing with genotypes or sequence reads. Bioinformatics, 33: 2056-2058. [link] [pdf] [supplement] [server website]


BE Cade, H Chen, AM Stilp, KJ Gleason, T Sofer, ..., C Wang, PC Zee, CL Hanis, SR Sunyaev, SR Patel, CC Laurie, X Zhu, R Saxena, X Lin, S Redline (2016). Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. American Journal of Respiratory and Critical Care Medicine, 194: 886-897. [link] [pdf]

H Chen*, C Wang*, MP Conomos, AM Stilp, Z Li, T Sofer, AA Szpiro, W Chen, JM Brehm, JC Celedon, S Redline, GJ Papanicolaou, TA Thornton, CC Laurie, K Rice, X Lin (2016). Control for population structure and relatedness for binary traits in genetic association studies via logistic mixed models. American Journal of Human Genetics, 98: 653-666. [link] [pdf] [supplement] [software]

X Lin, S Lee, M Wu, C Wang, H Chen, Z Li, X Lin (2016). Test for rare variants by environment interactions in sequencing association studies. Biometrics, 72: 156-164. [link] [pdf] [supplement] [software]


C Wang#, X Zhan, L Liang, GR Abecasis, X Lin (2015). Improved ancestry estimation for both genotyping and sequencing data using projection Procrustes analysis and genotype imputation. American Journal of Human Genetics, 96: 926-937. [link] [pdf] [supplement] [software] [media]


C Wang*#, X Zhan*, J Bragg-Gresham, HM Kang, D Stambolian, E Chew, K Branham, J Heckenlively, The FUSION Study, RS Fulton, RK Wilson, ER Mardis, X Lin, A Swaroop, S Zöllner, GR Abecasis# (2014). Ancestry estimation and control of population stratification for sequence-based association studies. Nature Genetics, 46: 409-415. [link] [pdf] [supplement] [software] [media]

X Zhan*, DE Larson*, C Wang*, DC Koboldt, Y Sergeev, 52 other coauthors, ER Mardis, A Swaroop, GR Abecasis (2013). Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nature Genetics, 45: 1375-1379. [link] [pdf] [supplement]

C Wang#, KB Schroeder, NA Rosenberg (2012). A maximum-likelihood method to correct for allelic dropout in microsatellite data with no replicate genotypes. Genetics 192: 651-669. [link] [pdf] [supplement] [software]

C Wang#, S Zöllner, NA Rosenberg (2012). A quantitative comparison of the similarity between genes and geography in worldwide human populations. PLoS Genetics 8: e1002886. [link] [pdf] [supplement] (Featured in Science)

TJ Pemberton, C Wang, JZ Li, NA Rosenberg (2010). Inference of unexpected genetic relatedness among individuals in HapMap Phase III. American Journal of Human Genetics 87: 457-464. [link] [pdf] [supplement] (Featured in Am. J. Hum. Genet. and Genetics)

C Wang, ZA Szpiech, J Degnan, M Jakobsson, TJ Pemberton, JA Hardy, AB Singleton, NA Rosenberg (2010). Comparing spatial maps of human population-genetic variation using Procrustes analysis. Statistical Applications in Genetics and Molecular Biology 9: 13. [link] [pdf]

JT Mosher, TJ Pemberton, K Harter, C Wang, EO Buzbas, P Dvorak, C Simon, SJ Morrison, NA Rosenberg (2010). Lack of population diversity in commonly used human embryonic stem-cell lines. New England Journal of Medicine 362: 183-185. [link] [pdf] [supplement] (Featured in Nature)

NM Kopelman, L Stone, C Wang, D Gefel, MW Feldman, J Hillel, NA Rosenberg (2009). Genomic microsatellites identify shared Jewish ancestry intermediate between Middle Eastern and European populations. BMC Genetics 10: 80. [link] [pdf]

L Huang, C Wang, NA Rosenberg (2009). The relationship between imputation error and statistical power in genetic association studie in diverse populations. American Journal of Human Genetics 85: 692-698. [link] [pdf] [supplement] (Featured in Am. J. Hum. Genet. and Nat. Rev. Genet.)