WANG LAB

Full Publications

* indicates co-first authors; # indicates corresponding authors; lab members are highlighted in bold.

2023

Hao X*#, Shao Z*, Zhang N*, Jiang M*, Cao X, Li S, Guan Y, Wang C#. Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture. Nature Communications, 2023, 14(1): 7498. [link]

Shi X, Yang Y, Ma X, Zhou Y, Guo Z, Wang C, Liu J. Probabilistic cell/domain-type assignment of spatial transcriptomics data with SpatialAnno. Nucleic Acids Research, 2023 (in press). [link]

Zhou M, Yang S, Cao L, Dai W, Nie X, Mu G, Zhang X, Wang B, Ma J, Wang D, Shi T, Wang C, Hao X, Chen W. Longitudinal association of polycyclic aromatic hydrocarbons and genetic risk with lung function. Environmental Pollution, 2023 340: 122801. [link]

Cheng S, Xu Z, Bian S, Chen X, Shi Y, Li Y, Duan Y, Liu Y, Lin J, Jiang Y, Jing J, Li Z, Wang Y, Meng X, Liu Y, Fang M, Jin X, Xu X, Wang J, Wang C, Li H, Liu S, Wang Y. The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay. Cell Discovery, 2023, 9(1): 75. [link]

Shi X, Qu M, Jiang Y, Zhu Z, Dai C, Jiang M, Ding L, Yan Y, Wang C，Zhang X, Cheng S#, Hao X#. Association of immune cell composition with the risk factors and incidence of acute coronary syndrome. Clinical Epigenetics, 2023, 15(1): 115. [link]

Lyu J, Guan X, Zhou Y, Guo H, Cheng S#, Wang C#. Risk prediction of hepatobiliary and pancreatic cancers in elderly Chinese: The Dongfeng-Tongji cohort. Journal of Evidence-Based Medicine, 2023, 16: 39-49. [link]

Wang H, Yuan Y, Wu B, Xiao M, Wang Z, Diao T, Zeng R, Chen L, Lei Y, Long P, Guo Y, Lai X, Wen Y, Li W, Cai H, Song L, Ni W, Zhao Y, Ouyang K, Wang J, Wang Q, Liu L, Wang C, Pan A, Li X, Gong R, Wu T. Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination among COVID-19 convalescents. Frontiers of Medicine, 2023, 17(4):747-757. [link]

Yu K, Lv J, Liu G, Yu C, Guo Y, Yang L, Chen Y, Wang C, Chen Z, Li L, Wu T. Cooking and future risk of all-cause and cardiopulmonary mortality. Nature Human Behavior, 2023, 7(2): 200-210. [link]

Wang H, Gan M, Wu B, Zeng R, Wang Z, Xu J, Li J, Zhang Y, Cao J, Chen L, Di D, Peng S, Lei J, Zhao Y, Song X, Yuan T, Zhou T, Liu Q, Yi J, Wang X, Cai H, Lei Y, Wen Y, Li W, Chen Q, Wang Y, Long P, Yuan Y, Wang C, Pan A, Wang Q, Gong R, Fan X, Wu T, Liu L. Humoral and cellular immunity of two-dose inactivated COVID-19 vaccination in Chinese children: a prospective cohort study. Journal of Medical Virology, 2023, 95(1): e28380. [link]

Tian DS*, Liu CC*, Wang C*, Qin C, Wang MH, Liu WH, Liu J, Zhang HW, Zhang RG, Wang SK, Zhang XX, Wang L, Pan DJ, Hu JP, Luo X, Xu SB, Wang W. Prevalence and risk factors of stroke in China: a national serial cross-sectional study from 2003 to 2018. Stroke Vascular Neurology, 2023, 8(3):238-248. [link]

2022

Kanoni S, Graham SE, Wang Y, et al. (including Wang C). Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biology, 2022, 23(1): 268. [link]

Yengo L, Vedantam S, Marouli E et al. (including Wang C). A saturated map of common genetic variants associated with human height. Nature, 2022, 610(7933): 704-712. [link]

Li W, Xu X, Jiang Q, Long P, Xiao Y, You Y, Jia C, Wang W, Lei Y, Xu J, Wang Y, Zhang M, Liu C, Zeng Q, Ruan S, Wang X, Wang C, Yuan Y, Guo H, Wu T. Circulating metals, leukocyte microRNAs and microRNA networks: A profiling and functional analysis in Chinese adults Environment International, 2022, 169: 107511. [link]

Lin C, Sun Z, Mei Z, Zeng H, Zhao M, Hu J, Xia M, Huang T, Wang C, Gao X, Zheng Y. The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study. BMC Medicine, 2022, 20(1): 414. [link]

Ramdas S, Judd J, Graham SE et al. (including Wang C). A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. American Journal of Human Genetics, 2022, 109(8): 1366-1387. [link]

Liu Q, Wu D, Wang C#. Identification of genomic regions distorting population structure inference in diverse continental groups. Quantitative Biology, 2022, 10(3): 287-298. [link] [codes]

Zhu Z, Wang K, Hao X, Chen L, Liu Z, Wang C#. Causal graph among serum lipids and glycemic traits: a Mendelian randomization study. Diabetes, 2022, 71(8):1818-1826. [link]

Wang K, Shi X, Zhu Z, Hao X, Chen L, Cheng S, Foo RSY, Wang C#. Mendelian randomization analysis of 37 risk factors and coronary artery disease in East Asian and European populations. Genome Medicine, 2022, 14(1): 63. [link] [codes]

Winkler TW, Rasheed H, Teumer A, Gorski M, Rowan BX, et al. (including Wang C). Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals. Communications Biology, 2022, 5(1): 580. [link]

Ma J*, Hao X*, Nie X, Yang S, Zhou M, Wang D, Wang B, Cheng M, Ye Z, Xie Y, Wang C#, Chen W#. Longitudinal relationships of polycyclic aromatic hydrocarbons exposure and genetic susceptibility with blood lipid profiles. Environment International, 2022, 164: 107259. [link]

Liu X, Shen M, Yan H, Long P, Jiang H, Zhang Y, Zhou L, Yu K, Qiu G, Yang H, Li X, Min X, He M, Zhang X, Choi H, Wang C#, Wu T#. Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina. Journal of Genetics and Genomics, 2022, 49: 240-248. [link]

Cheng S*, Lyu J*, Shi X, Wang K, Wang Z, Deng M, Sun B#, Wang C#. Rare variant association tests for ancestry-matched case-control data based on conditional logistic regression. Briefings in Bioinformatics, 2022, 23(2): bbab572. [link] [software]

2021

The Global Lipids Genetics Consortium (GLGC, including Wang C). The power of genetic diversity in genome-wide association studies of lipids. Nature, 2021, 600(7890): 675-679. [link]

Dai C, Chen M, Wang C, Hao X#. Deconvolution of bulk gene expression profiles with single-cell transcriptomics to develop a cell type composition-based prognostic model for acute myeloid leukemia. Frontiers in Cell and Developmental Biology, 2021, 9: 762260. [link]

Wu P*, Ding L*, Li X*, Liu S*, Cheng F*, He Q*, Xiao M, Wu P, Hou H, Jiang M, Long P, Wang H, Liu L, Qu M, Shi X, Jiang Q, Mo T, Ding W, Fu Y, Han S, Huo X, Zeng Y, Zhou Y, Zhang Q, Ke J, Xu X, Ni W, Shao Z, Wang J, Liu P, Li Z, Jin Y, Zheng F, Wang F, Liu L, Li W, Liu K, Peng R, Xu X, Lin Y, Gao H, Shi L, Geng Z, Mu X, Yan Y, Wang K, Wu D, Hao X, Cheng S, Qiu G, Guo H, Li K, Chen G, Sun Z, Lin X, Jin X#, Wang F#, Sun C#, Wang C#. Trans-ethnic genome-wide association study of severe COVID-19. Communications Biology, 2021, 4(1): 1034. [link]

Wu D, Li PY, Pan B, Tiang Z, Dou J, Williantarra I, Pribowo AY, Nurdiansyah R; SG Peranakan Project, Foo RSY#, Wang C#. Genetic admixture in the culturally unique Peranakan Chinese population in Southeast Asia. Molecular Biology and Evolution, 2021, 38(10): 4463-4474. [link]

Wang K*, Qu M*, Ding L, Shi X, Wang C, Cheng S#, Hao X#. Liver and kidney function biomarkers, blood cell traits and risk of severe COVID-19: a Mendelian randomization study. Frontiers in Genetics, 2021, 12:647303. [link]

Wang H*, Yuan Y*, Xiao M, Chen L, Zhao Y, Zhang H, Long P, Zhou Y, Xu X, Lei Y, Wu B, Diao T, Cai H, Liu L, Shao Z, Wang J, Bai Y, Wang K, Peng M, Liu L, Han S, Mei F, Cai K, Lei Y, Pan A, Wang C, Gong R#, Li X#, Wu T#. Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection. Cellular & Molecular Immunology, 2021, 18(7): 1832-1834. [link]

The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC, including Wang C). The trans-ancestral genomic architecture of glycemic traits. Nature Genetics, 2021, 53(6): 840-860. [link]

Shen M, Xu X, Liu X, Wang Q, Li W, You X, Peng R, Yuan Y, Long P, Niu R, Yang H, Cheng X, Pan A, Tanguay RM, Zhang X, He M, Wang C, Liang L, Wu T. Prospective study on plasma microRNA-4286 and incident acute coronary syndrome. Journal of the American Heart Association, 2021, 10(6): e018999. [link]

Tu Y, Yang P, Zhou Y, Wen X, Li Q, Zhou J, Wang J, Hu J, He N, Wang K, Wang C, Tian X, Luo A, Gao F. Risk factors for mortality of critically ill patients with COVID-19 receiving invasive ventilation. International Journal of Medical Sciences, 2021, 18(5): 1198-1206 [link]

Fu Y, Li Y, Guo E, He L, Liu J, Yang B, Li F, Wang Z, Li Y, Xiao R, Liu C, Huang Y, Wu X, Lu F, You L, Qin T, Wang C, Li K, Wu P#, Ma D#, Sun C#, Chen G#. Dynamics and correlation among viral positivity, seroconversion, and disease severity in COVID-19: a retrospective study. Annals of Internal Medicine, 2021, 174(4):453-461 [link]

Dou J*, Wu D*, Ding L, Wang K, Jiang M, Chai C, Reilly DF, Tai ES, Liu J, Sim X, Cheng S#, Wang C#. Using off-target data from whole-exome sequencing to improve genotyping accuracy, association analysis, and polygenic risk prediction. Briefings in Bioinformatics, 2021, 22(3): bbaa084. [link] [software]

2020

Wang K, Ding L, Yang C, Hao X#, Wang C#. Exploring the relationship between psychiatric traits and the risk of mouth ulcers using bi-directional Mendelian randomization. Frontiers in Genetics, 2020, 11: 608630. [link]

Yonova-Doing E*, Zhao W*, Igo RP Jr*, Wang C*, Sundaresan P, Lee KE, Jun GR, Alves AC, Chai X, Chan ASY, Lee MC, Fong A, Tan AG, Khor CC, Chew EY, Hysi PG, Fan Q, Chua J, Chung J, Liao J, Colijn JM, Burdon KP, Fritsche LG, Swift MK, Hilmy MH, Chee ML, Tedja M, Bonnemaijer PWM, Gupta P, Tan QS, Li Z, Vithana EN, Ravindran RD, Chee SP, Shi Y, Liu W, Su X, Sim X, Shen Y, Wang YX, Li H, Tham YC, Teo YY, Aung T, Small KS, Mitchell P, Jonas JB, Wong TY, Fletcher AE, Klaver CCW, Klein BEK, Wang JJ, Iyengar SK, Hammond CJ#, Cheng CY#. Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract. Communications Biology, 2020, 3(1): 755. [link]

Chai JF, Kao SL, Wang C, Lim VJ, Khor IW, Dou J, Podgornaia AI, Chothani S, Cheng CY, Sabanayagam C, Wong TY, van Dam RM, Liu J, Reilly DF, Paterson AD, Sim X. Genome-wide association for HbA1c in Malay identified deletion on SLC4A1 that influences HbA1c independent of glycemia. Journal of Clinical Endocrinology & Metabolism, 2020, 105(12): dgaa658. [link]

Hao X#, Wang K, Dai C, Ding Z, Yang W, Wang C, Cheng S#. Integrative analysis of scRNA-seq and GWAS data pinpoints periportal hepatocytes as the relevant liver cell types for blood lipids. Human Molecular Genetics, 2020, 29(18): 3145-3153. [link]

Hao X*, Cheng S*, Wu D*, Wu T#, Lin X#, Wang C#. Reconstruction of the full transmission dynamics of COVID-19 in Wuhan. Nature, 2020, 584: 420-424. [link] [codes] [Nature cover] [Nature blog] [Nature highlight] [Nature news on the preprint]

Pan A*, Liu L*, Wang C*, Guo H*, Hao X*, Wang Q, Huang J, He N, Yu H, Lin X#, Wei S#, Wu T#. Association of public health interventions with the epidemiology of the COVID-19 outbreak in Wuhan, China. Journal of the American Medical Association, 2020, 323(19): 1915-1923. [link] [JAMA editorial] [JAMA insights]

Leong A, Lim VJY, Wang C, Chai JF, Dorajoo R, Heng CK, van Dam RM, Koh WP, Yuan JM, Jonas JB, Wang YX, Wei WB, Liu J, Reilly DF, Wong TY, Cheng CY, Sim X. Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals. BMJ Open Diabetes Research & Care, 2020, 8(1): e001091. [link]

Yu K*, Lv J*, Qiu G*, Yu C, Guo Y, Bian Z, Yang L, Chen Y, Wang C, Pan A, Liang L, Hu FB, Chen Z, Li L#, Wu T# for the China Kadoorie Biobank Study. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study. Lancet Global Health, 2020, 8(3): e430-e439. [link]

Wang K, Xu Y, Wang C, Tan M, Chen P#. A corrected goodness-of-fit index (CGFI) for model evaluation in structural equation modeling. Structural Equation Modeling: A Multidisciplinary Journal, 2020, 27(5): 735-749. [link]

2019

D Wu*, J Dou*, X Chai*, C Bellis, A Wilm, CC Shih, WWJ Soon, N Bertin, CB Lin, CC Khor, M DeGiorgio, S Cheng, L Bao, N Karnani, WYK Hwang, S Davila, P Tan, A Shabbir, A Moh, EK Tan, JN Foo, LL Goh, KP Leong, RSY Foo, CSP Lam, AM Richards, CY Cheng, T Aung, TY Wong, HH Ng, SG10K Consortium, J Liu#, C Wang# (2019). Large-scale whole-genome sequencing of three diverse Asian populations in Singapore. Cell, 179(3): 736-749. [link] (Featured as the Cover Article)

A Teumer*, Y Li*, S Ghasemi*, BP Prins*, M Wuttke*, T Hermle*, ..., C Wang, ..., AS Butterworth#, AM Hung#, C Pattaro#, A Köttgen# (2019). Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nature Communications, 10(1): 4130. [link]

K Huang*, T Yang*, J Xu*, L Yang*, J Zhao*, X Zhang*, C Bai*, J Kang*, P Ran*, H Shen*, F Wen*, W Yao*, T Sun*, G Shan*, Y Lin*, G Xu*, S Wu*, C Wang, ..., T Wu, KF Chung, J He, Chen Wang# for the China Pulmonary Health (CPH) Study Group (2019). Prevalence, risk factors and management of asthma in China: a national cross-sectional study. Lancet, 394(10196): 407-418. [link]

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski, A Tin, L Wang, ..., C Wang, ..., K Stefansson, AM Hung, IM Heid, M Scholz, A Teumer, A Köttgen, C Pattaro.(2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51(6): 957-972. [link]

H Chen, JE Huffman, JA Brody, C Wang, S Lee, ..., CC Laurie, AC Morrison, KM Rice, X Lin (2019). Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies. American Journal of Human Genetics, 104(2): 260-274. [link]

2018

F Takeuchi, M Akiyama, N Matoba, T Katsuya, M Nakatochi, ..., C Wang, ..., T Nabika, M Yokota, Y Kamatani, M Kubo, N Kato (2018). Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications, 9(1): 5052. [link]

H Chen, BE Cade, KJ Gleason, AC Bjonnes, AM Stilp, ..., C Wang, ..., X Zhu, SR Sunyaev, R Saxena, X Lin, S Redline (2018). Multi-ethnic Meta-analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea Related Quantitative Trait Locus in Men. American Journal of Respiratory Cell and Molecular Biology, 58(3): 391-401. [link]

2017

J Liu*, X Wan*, C Wang, Ch Yang, X Zhou, C Yang# (2017). LLR: A latent low-rank approach to colocalizing genetic risk variants in multiple GWAS. Bioinformatics, 33: 3878-3886. [link] [pdf] [supplement]

H Liu*, Z Wang*, Y Li*, G Yu, X Fu, ..., C Wang, ..., S Chen, J Liu, F Zhang# (2017). Genome-wide analysis of protein-coding variants in leprosy. Journal of Investigative Dermatology, 137: 2544-2551. [link] [pdf] [supplement]

X Wang, Z Zhang, N Morris, T Cai, S Lee, C Wang, TW Yu, CA Walsh, X Lin (2017). Rare variant association test in family based sequencing studies. Briefings in Bioinformatics, 18(6): 954–961. [link] [pdf] [supplement]

J Dou*, B Sun*, X Sim, JD Hughes, DF Reilly, ES Tai, J Liu, C Wang# (2017). Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data. PLOS Genetics, 13: e1007021. [link] [pdf] [supplement] [software]

W Dai, M Yang, C Wang, T Cai (2017). Sequence robust association test (SRAT) for familial data. Biometrics, 73: 876-884. [link] [pdf] [supplement]

Z Wang, BC Henn, C Wang, Y Wei, L Su, R Sun, H Chen, PJ Wagner, Q Lu, X Lin, R Wright, D Bellinger, M Kile, M Mazumdar, MM Tellez-Rojo, L Schnaas, DC Christiani (2017). Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environmental Health, 16: 81. [link] [pdf]

D Taliun#, S Chothani, S Schonherr, L Forer, M Boehnke, GR Abecasis, C Wang# (2017). LASER server: ancestry tracing with genotypes or sequence reads. Bioinformatics, 33: 2056-2058. [link] [pdf] [supplement] [server website]

2016

BE Cade, H Chen, AM Stilp, KJ Gleason, T Sofer, ..., C Wang, PC Zee, CL Hanis, SR Sunyaev, SR Patel, CC Laurie, X Zhu, R Saxena, X Lin, S Redline (2016). Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. American Journal of Respiratory and Critical Care Medicine, 194: 886-897. [link] [pdf]

H Chen*, C Wang*, MP Conomos, AM Stilp, Z Li, T Sofer, AA Szpiro, W Chen, JM Brehm, JC Celedon, S Redline, GJ Papanicolaou, TA Thornton, CC Laurie, K Rice, X Lin (2016). Control for population structure and relatedness for binary traits in genetic association studies via logistic mixed models. American Journal of Human Genetics, 98: 653-666. [link] [pdf] [supplement] [software]

X Lin, S Lee, M Wu, C Wang, H Chen, Z Li, X Lin (2016). Test for rare variants by environment interactions in sequencing association studies. Biometrics, 72: 156-164. [link] [pdf] [supplement] [software]

2015

C Wang#, X Zhan, L Liang, GR Abecasis, X Lin (2015). Improved ancestry estimation for both genotyping and sequencing data using projection Procrustes analysis and genotype imputation. American Journal of Human Genetics, 96: 926-937. [link] [pdf] [supplement] [software] [media]

2009-2014

C Wang*#, X Zhan*, J Bragg-Gresham, HM Kang, D Stambolian, E Chew, K Branham, J Heckenlively, The FUSION Study, RS Fulton, RK Wilson, ER Mardis, X Lin, A Swaroop, S Zöllner, GR Abecasis# (2014). Ancestry estimation and control of population stratification for sequence-based association studies. Nature Genetics, 46: 409-415. [link] [pdf] [supplement] [software] [media]

X Zhan*, DE Larson*, C Wang*, DC Koboldt, Y Sergeev, 52 other coauthors, ER Mardis, A Swaroop, GR Abecasis (2013). Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. Nature Genetics, 45: 1375-1379. [link] [pdf] [supplement]

C Wang#, KB Schroeder, NA Rosenberg (2012). A maximum-likelihood method to correct for allelic dropout in microsatellite data with no replicate genotypes. Genetics 192: 651-669. [link] [pdf] [supplement] [software]

C Wang#, S Zöllner, NA Rosenberg (2012). A quantitative comparison of the similarity between genes and geography in worldwide human populations. PLoS Genetics 8: e1002886. [link] [pdf] [supplement] (Featured in Science)

TJ Pemberton, C Wang, JZ Li, NA Rosenberg (2010). Inference of unexpected genetic relatedness among individuals in HapMap Phase III. American Journal of Human Genetics 87: 457-464. [link] [pdf] [supplement] (Featured in Am. J. Hum. Genet. and Genetics)

C Wang, ZA Szpiech, J Degnan, M Jakobsson, TJ Pemberton, JA Hardy, AB Singleton, NA Rosenberg (2010). Comparing spatial maps of human population-genetic variation using Procrustes analysis. Statistical Applications in Genetics and Molecular Biology 9: 13. [link] [pdf]

JT Mosher, TJ Pemberton, K Harter, C Wang, EO Buzbas, P Dvorak, C Simon, SJ Morrison, NA Rosenberg (2010). Lack of population diversity in commonly used human embryonic stem-cell lines. New England Journal of Medicine 362: 183-185. [link] [pdf] [supplement] (Featured in Nature)

NM Kopelman, L Stone, C Wang, D Gefel, MW Feldman, J Hillel, NA Rosenberg (2009). Genomic microsatellites identify shared Jewish ancestry intermediate between Middle Eastern and European populations. BMC Genetics 10: 80. [link] [pdf]

L Huang, C Wang, NA Rosenberg (2009). The relationship between imputation error and statistical power in genetic association studie in diverse populations. American Journal of Human Genetics 85: 692-698. [link] [pdf] [supplement] (Featured in Am. J. Hum. Genet. and Nat. Rev. Genet.)